Work

Human skin models: From healthy to disease‐mimetic systems; characteristics and applications

Year: 2020

Type: review

Abstract: Skin drug delivery is an emerging route in drug development, leading to an urgent need to understand the behaviour of active pharmaceutical ingredients within the skin. Given, As one of the body's first natural defences, the barrier properties of skin provide an obstacle to the successful outcome of any skin drug therapy. To elucidate the mechanisms underlying this barrier, reductionist strategies have designed several models with different levels of complexity, using non-biological and biological components. Besides the detail of information and resemblance to human skin in vivo, offered by each in vitro model, the technical and economic efforts involved must also be considered when selecting the most suitable model. This review provides an outline of the commonly used skin models, including healthy and diseased conditions, in-house developed and commercialized models, their advantages and limitations, and an overview of the new trends in skin-engineered models.

Source: British Journal of Pharmacology

DOI: 10.1111/bph.15184

Authors: Tânia Moniz, Sofia A. Costa Lima, Salette Reis

Institutions: Universidade do Porto, Rede de Química e Tecnologia, LAQV Requimte

Language: English

Topic: Advancements in Transdermal Drug Delivery

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Fundação para a Ciência e a Tecnologia, European Regional Development Fund