Year: 2020
Type: article
Abstract: Insulin is stored in secretory granules to facilitate rapid release in response to rising glucose levels, but the mechanisms by which these granules are identified and prioritized for secretion remains unclear. Using a fluorescent timer and flow cytometry–assisted organelle sorting, Yau et al. develop an elegant approach to assess insulin secretion as a function of granule age in pancreatic islet beta cells. Their findings supply quantitative evidence supporting the age-dependent release of different granule pools and confirm earlier models of preferential release of younger granules.
Source: Journal of Biological Chemistry
Authors: Eleni Georgiadou, Guy A. Rutter
Institutions: Imperial College London, Nanyang Technological University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
Awards: Genetic and nutritional control of pancreatic beta cell identity., Roles of GWA genes in controlling pancreatic beta cell function and mass., G2400843396, Role of mitochondrial calcium transport in the regulation of insulin secretion, G4135502656, Ligand bias at the GLP-1 receptor as a means of favouring cytoprotection, Targeting etiologic molecular mechanisms to treat human diabetes, G5877155211, Role and regulation of GLP-1 receptor trafficking in pancreatic beta cells, Targeting GLP-1 receptor trafficking to improve therapies for type 2 diabetes, G7005210393, Determining the role of arcuate nucleus glucokinase in the regulation of glucose homeostasis, Roles of the type 2 diabetes (T2D)-associated gene C2cd4a in regulating glucose homeostasis in the mouse, G9000168923
OpenAlex ID: W3039701170