Year: 2020
Type: article
Abstract: Although cerebral blood flow (CBF) alterations are associated with Alzheimer’s disease (AD), CBF patterns across prodromal stages of AD remain unclear. Therefore, we investigated patterns of regional CBF in 162 Alzheimer’s Disease Neuroimaging Initiative participants characterized as cognitively unimpaired (CU; n = 80), objectively-defined subtle cognitive decline (Obj-SCD; n = 31), or mild cognitive impairment (MCI; n = 51). Arterial spin labeling MRI quantified regional CBF in a priori regions of interest: hippocampus, inferior temporal gyrus, inferior parietal lobe, medial orbitofrontal cortex, and rostral middle frontal gyrus. Obj-SCD participants had increased hippocampal and inferior parietal CBF relative to CU and MCI participants and increased inferior temporal CBF relative to MCI participants. CU and MCI groups did not differ in hippocampal or inferior parietal CBF, but CU participants had increased inferior temporal CBF relative to MCI participants. There were no CBF group differences in the two frontal regions. Thus, we found an inverted-U pattern of CBF signal across prodromal AD stages in regions susceptible to early AD pathology. Hippocampal and inferior parietal hyperperfusion in Obj-SCD may reflect early neurovascular dysregulation, whereby higher CBF is needed to maintain cognitive functioning relative to MCI participants, yet is also reflective of early cognitive inefficiencies that distinguish Obj-SCD from CU participants.
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1032285814, G104586243, G1174407038, G1471156645, Cerebral Arterial Compliance and Cognitive Function in MCI, G1775224375, G2189010064, Cognitive Process Scores to Improve Preclinical AD Detection, G2835601961, Re-visiting Methods for MCI Diagnosis to Improve Biomarker and Trial Findings, G29951154, G3486991840, G363319880, G4119534169, G4161414584, Identifying best methods for the detection of subtle cognitive decline, G4475667458, G4634358690, G4673940345, G497807829, New Quantitative Neuroimaging Metrics of Structural and Functional Connectivity of the Locus Coeruleus as a Novel Biomarker of Alzheimer's Disease Pathogenesis and Progression, G5207404921, G5324093878, G5363700876, G5678256514, Alzheimer's Disease Neuroimaging Initiative, G5850682332, G665855531, Longitudinal Cognitive and Biomarker Trajectories of MCI Subtypes, G6804111827, G8895907669, G9000039018, G9000122335
OpenAlex ID: W3039890225