Work

Semimechanistic Modeling of Eravacycline Pharmacodynamics Using In Vitro Time-Kill Data with MIC Incorporated in an Adaptive Resistance Function

Year: 2020

Type: article

Abstract: Effective bacterial infection eradication requires not only potent antibacterial agents but also proper dosing strategies. Current practices generally utilize point estimates of the effects of therapeutic agents, even though the actual kinetics of exposure are much more complex and relevant. Here, we use a full time course of the observed in vitro effects to develop a semimechanistic pharmacokinetic-pharmacodynamic model for eravacycline against multiple Gram-negative bacterial pathogens.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01308-20

Authors: Ken Nguyen, Timothy J. Bensman, Xiaohui (Tracey) Wei, Jason N. Moore

Institutions: United States Food and Drug Administration, Center for Drug Evaluation and Research, Walter Reed Army Institute of Research

Language: English

Topic: Antibiotics Pharmacokinetics and Efficacy

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3039931161

FWCI: 0.15

Cites: 25

Cited by: 1

Related to: 10