Year: 2021
Type: article
Abstract: In sexually reproducing animals, the oocyte contributes a large supply of RNAs that are essential to launch development upon fertilization. The mechanisms that regulate the composition of the maternal RNA contribution during oogenesis are unclear. Here, we show that a subset of RNAs expressed during the early stages of oogenesis is subjected to regulated degradation during oocyte specification. Failure to remove these RNAs results in oocyte dysfunction and death. We identify the RNA-degrading Super Killer complex and No-Go Decay factor Pelota as key regulators of oogenesis via targeted degradation of specific RNAs expressed in undifferentiated germ cells. These regulators target RNAs enriched for cytidine sequences that are bound by the polypyrimidine tract binding protein Half pint. Thus, RNA degradation helps orchestrate a germ cell-to-maternal transition that gives rise to the maternal contribution to the zygote.
Source: Current Biology
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $6,700
Awards: Role of RNA degradation in germline stem cell to oocyte transition, Transcriptome reprogramming in the early embryo, G2264443168, Regulation of stem cell differentiation during Drosophila oogenesis, G3558539861, Regulated RNA degradation is required for Drosophila oogenesis, Critical Analysis of a Rapid 4-compartment Model in Hispanic Adults:Effect of Age and Level of Body Fatness
OpenAlex ID: W3161442509