Work

Muscle-derived Myoglianin regulates Drosophila imaginal disc growth

Year: 2020

Type: article

Abstract: the BMP family member Dpp is produced in a limited set of imaginal disc cells and functions as a classic morphogen to regulate pattern and growth by diffusing throughout imaginal discs. However, the role of TGFβ/Activin-like ligands in disc growth control remains ill-defined. Here, we demonstrate that Myoglianin (Myo), an Activin family member, and a close homolog of mammalian Myostatin (Mstn), is a muscle-derived extrinsic factor that uses canonical dSmad2-mediated signaling to regulate wing size. We propose that Myo is a myokine that helps mediate an allometric relationship between muscles and their associated appendages.

Source: eLife

DOI: 10.7554/elife.51710

Authors: Ambuj Upadhyay, Aidan J Peterson, Myung-Jun Kim, Michael B O'Connor

Institution: University of Minnesota

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,500

Funder: National Institute of General Medical Sciences