Ultradeep analysis of pretherapy HIV predicts large and genetically complex reservoirs during antiretroviral therapy
Year: 2019
Type: article
Study design: Observational Study
Abstract: Journal of Virus Eradication 2019; 5 (Supplement 3): 1-58 27 (MPD) of unique sequences for each patient showed that env and nef were the most variable genes.The MPD observed in different patients correlated with the time before treatment initiation (r=0.96,p=0.003), suggesting that the complexity of the replication-competent reservoir mirrors that present at treatment initiation.No correlation was observed between MPD and the duration of successful treatment (mean 8 years, range 2-15).Consistent with genotypic data, a broader range of infectivity (up to 100-fold) was observed among isolates from patients with delayed treatment initiation than in those treated early.Conclusions: This work unveiled differences in the genotypic and phenotypic properties of reservoir viruses from treated patients, and suggests that delaying treatment Results: in increased diversity.These findings are relevant for strategies aiming the reduction of the reservoir.
Source: Journal of Virus Eradication
Authors: K. Huik, J. Hattori, V. Boltz, J. Rausch, W. Shao, M. Kearney, J. Coffin, F. Maldarelli
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W3040756884