Work

Impact of anti-PD-1 and anti-CTLA-4 on the HIV reservoir in vivo: AMC-095 Study

Year: 2019

Type: article

Abstract: Conclusion: Suppressive therapy significantly prevents HIV sexual transmission (Undetectable = Untransmittable).Under therapy, however, immunocaptured seminal variants had evidence of large genetic distances (>2%) relative to blood viruses.This has implications for assessing genotypic linkage if insufficient suppression leads to their transmission.Detectable seminal virus was not associated with INSTI resistance.

Source: Journal of Virus Eradication

DOI: 10.1016/s2055-6640(20)30173-4

Authors: SharonR Lewin, Thomas A. Rasmussen, Laskhmi Rajdev, Ajantha Rhodes, Ashanti Dantanarayana, Surekha Tennakoon, Socheata Chea, Danielle Rigau, Shelly Lensing, Rachel Rutishauser, Sonia Bakkour, Michael Busch, Dirk P. Dittmer, Steven Deeks, Christine Durand

Institutions: The Royal Melbourne Hospital, The University of Melbourne, The Alfred Hospital, Peter Doherty Institute, Monash University, Albert Einstein College of Medicine, Johns Hopkins University, University of Arkansas for Medical Sciences, University of California, San Francisco, Vitalant Research Institute, University of North Carolina at Chapel Hill

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950

OpenAlex ID: W3040868402

FWCI: 0.125

Cites:

Cited by: 1

Related to: 10