Intensive versus standard mass anthelminthic treatment reduces innate immune dampening among individuals from Ugandan fishing villages
Year: 2019
Type: other
Abstract: Objective: Investigate the effect of intensive versus standard mass worm treatment on the innate immune response in high-worm-burden Ugandan fishing villages. Methods: Community members in selected households were selected at random into two treatment clusters: 1. Standard arm (single-dose albendazole twice a year and a single-dose praziquantel yearly) 2. Intensive arm (quarterly triple-dose albendazole [daily, three days] and quarterly single-dose praziquantel). Forty-seven participants from the outcome survey conducted after three years of mass drug administration were considered for this sub-study. Whole blood collected from these participants was cultured with a panel of innate stimuli for 24 hours. Soluble immunological molecules in culture supernatants were measured using Luminex® assay. Relationship between innate immune responses and treatment arm, and patterns of soluble molecules were examined. Results: Intensive treatment was associated with an increased IL-8 and VEGF responses, but a decreased IL-10 response to innate stimuli. However, evaluation of patterns of soluble immunological molecules and their relationships with treatment arms showed no differences. Conclusion: Intensive treatment was associated with an increased pro-inflammatory immune response profile, and a reduced regulatory innate immune response profile. Treatment and subsequent reduction of worm burden in infected individuals may enhance immune responses to vaccines and other infectious pathogens.
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3040962575