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No evidence for ongoing HIV replication in lymph nodes during suppressive ART

Year: 2017
Type: article
Abstract: aviremic and viremic patients also co-expressed the CD32a marker (90% of all infected cells), while most of CD32a single positive cells were absent from the B cell follicle, one of the major reservoirs for HIV.HIV infection of unstimulated pbmcs and cervico-vaginal histocultures upregulated the expression of CD32 in approximately 10-20% of all infected cells.CD32+ infected cells expressed more frequently the activation marker HLA-DR compared to CD32-infected cells (92% vs 77%) and the immune check-point PD-1 (46% vs 25%).Conclusions: CD32 is preferentially detected in HIV transcriptionally active cells in tissues after ART and was identified to be co-expressed with activation markers in in vitro infected cells suggesting its expression is also associate with active HIV-infected cells.
DOI: 10.1016/s2055-6640(20)30542-2
Authors: W.R. McManus, M.J. Bale, J. Spindler, A. Wiegand, A. Musick, X. Wu, D. Wells, S.H. Hughes, B.F. Keele, R. Hoh, J. Mulish, J.M. Coffin, J.W. Mellors, S.G. Deeks, M.F. Kearney
Institutions: National Cancer Institute, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc. (United States), University of California, San Francisco, Tufts University, University of Pittsburgh
Language: English
Subfield: Virology
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W3041076792
FWCI: 0.447
Cites:
Cited by: 3
Related to: 10