High latent Tuberculosis prevalence and poor metabolic outcomes among Type 2 Diabetic Mellitus patients in Uganda: a case control study
Year: 2019
Type: other
Abstract: Objectives:Patients with type 2 diabetes mellitus (T2DM) are three times more at risk of acquiring tuberculosis (TB) compared to non-diabetic individuals. Our study aim was to find out the prevalence of latent TB among newly diagnosed T2DM patients attending the diabetic clinic at Mulago National Referral Hospital (MNRH) in Kampala, Uganda. Methods:This was a case control study carried out between October 2017 and March 2018. Patients seeking care at MNRH were screened, and 103 newly diagnosed T2DM cases enrolled. Controls of similar age and gender were also screened, and 201 enrolled. Latent TB was diagnosed using a blood test and chest X-rays. Results:The prevalence of latent TB was 73% among cases and 71% among controls. Most of the cases and controls were female (69% and 71% respectively). Cases had poor blood sugar control and were more overweight. Also, the cases had worse symptoms than controls such as higher blood pressure and cholesterol levels. About 17% of the T2DM cases had signs of kidney disease. Among controls, 10% were pre-diabetic. Conclusions:There was no difference in the prevalence of latent TB between T2DM cases and their controls. The burden of latent TB was high among both populations. T2DM cases had worse symptoms, predisposing them to more complications and death.
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3041350946