Corrigendum to ‘Cyclic AMP-Responsive element-binding protein (CREB) is critical in autoimmunity by promoting Th17 but inhibiting treg cell differentiation’
Year: 2020
Type: erratum
Abstract: The authors regret that, in the originally published Supplementary Data, two flow images were inadvertently duplicated and introduced in Supplementary Fig 5A, due to copying errors. We have gone through our original data and reanalyzed the whole set of flow images for Supplementary Fig. 5A, and corrected the above errors online. The reanalyzed data are highly consistent with the original non-duplicated data in the paper, and this correction has not changed the description, interpretation, or the original conclusions of the manuscript (the newly revised data are shown below). Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell DifferentiationThe molecular mechanisms that govern differential T cell development into pro-inflammatory Th17 vs. regulatory T (Treg) cells remain unclear. Here, we show that selective deletion of CREB in T cells or Th17 cells impaired Th17 cell differentiation in vitro and in vivo, and led to resistance to autoimmune diseases. Mechanistically, CREB, activated by CD3-PKC-ϴ signaling, plays a key role in regulating Th17 cell differentiation, at least in part through directly binding to the Il17-Il17f gene locus. Full-Text PDF Open Access
Source: EBioMedicine
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,500
OpenAlex ID: W3041386876