NNK-mediated upregulation of DEPDC1 stimulates the progression of oral squamous cell carcinoma by inhibiting CYP27B1 expression.
Year: 2020
Type: article
Abstract: . These findings suggest that smoking causes DEPDC1 overexpression in OSCC through DNMT1-regulated DNA methylation and that upregulated DEPDC1 stimulates OSCC cell proliferation by inhibiting CYP27B1 expression. Our results establish a new mechanism of OSCC progression and highlight DEPDC1 as a candidate prognostic biomarker and therapeutic target in OSCC.
Source: PubMed
Authors: Junfeng Guo, Shuzuo Zhou, Ping Huang, Shuai Xu, Gang Zhang, Haitao He, Yi Zeng, Cheng-Xiong Xu, Haesung Kim, Yinghui Tan
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3041562137