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No residual virus replication in a randomised trial of dolutegravir intensification

Year: 2017
Type: article
Abstract: the pre-ART plasma phylogeny, but did not specifically align within rebound lineages.Expanded clones comprised 30% to 95% of participants' reservoirs, with similar frequencies pre-and post-ATI.Thus, sequences showed no evidence for enrichment of rebound viruses post-trial and pre-trial QVOA viruses failed to predict the identity of rebound virus.Pre-ART, rebound and QVOA Envs for each participant had similar IC50s to VRC01.Conclusions: Quantitative and phylogenetic analyses suggest a brief ATI does not expand the latent reservoir.While clonal QVOA populations comprised a substantial fraction of replication competent peripheral latent virus, they did not rebound in vivo upon ATI despite similar VRC01 sensitivities.Results provide reassurance for participants of clinical trials employing ATI and highlight the challenge of accurately characterizing the full range of the replication competent latent reservoir that reactivates in vivo.
DOI: 10.1016/s2055-6640(20)30555-0
Authors: T.A. Rasmussen, J. McMahon, J. Chang, J. Audsley, A. Rhodes, S. Tennakoon, A. Dantanarayana, T. Spelman, T. Schmidt, S.J. Kent, V. Morcilla, S. Palmer, J. Elliott, S.R. Lewin
Institutions: The Royal Melbourne Hospital, The University of Melbourne, Aarhus University Hospital, Peter Doherty Institute, The Alfred Hospital, Monash University, Melbourne Sexual Health Centre, Alfred Health, The University of Sydney, Westmead Institute for Medical Research
Language: English
Subfield: Virology
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W3041573612
FWCI: 0.15
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Cited by: 1
Related to: 10