Work

Photoacoustic topography through an ergodic relay for functional imaging and biometric application in vivo

Year: 2020

Type: article

Abstract: SIGNIFICANCE: Photoacoustic (PA) tomography has demonstrated versatile biomedical applications. However, an array-based PA computed tomography (PACT) system is complex and expensive, whereas a single-element detector-based scanning PA system is too slow to detect some fast biological dynamics in vivo. New PA imaging methods are sought after. AIM: To overcome these limitations, we developed photoacoustic topography through an ergodic relay (PATER), a novel high-speed imaging system with a single-element detector. APPROACH: PATER images widefield PA signals encoded by the acoustic ergodic relay with a single-laser shot. RESULTS: We applied PATER in vivo to monitor changes in oxygen saturation in a mouse brain and also to demonstrate high-speed matching of vascular patterns for biometric authentication. CONCLUSIONS: PATER has achieved a high-speed temporal resolution over a large field of view. Our results suggest that PATER is a promising and economical alternative to PACT for fast imaging.

Source: Journal of Biomedical Optics

DOI: 10.1117/1.jbo.25.7.070501

Authors: Yang Li, Lei Li, Liren Zhu, Junhui Shi, Konstantin Maslov, Lihong V. Wang

Institutions: California Institute of Technology, Washington University in St. Louis

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,675

Funders: National Institutes of Health, National Cancer Institute, National Institute of Neurological Disorders and Stroke