Measuring the Construct of Clinical Utility in the Context of Genetic Testing: A Scoping Review
Year: 2019
Type: dissertation
Abstract: Understanding how clinical utility is measured across a range of clinical scenarios can provide strategies for operationalizing this construct, in turn supporting more consistent and robust evaluations of genetic tests. The current scoping review explored the range of outcomes used to measure the value of genetic testing in the literature, spanning 2015-2017. The search strategy and data analysis were guided by the Fryback and Thornbury (F-T) Hierarchical Model of Efficacy. In total, 194 peer-reviewed evaluative studies that used experimental or observational designs were included in this review. Findings herein suggest that additional clinical areas, more robust study designs and novel strategies for measuring the construct of clinical utility are warranted. Additionally, the results suggest refinements to the meaning and content of the domains embedded in the F-T framework. These results can inform future systematic reviews, research design in genetic test evaluative studies and reflections on the concept of clinical utility.
Source: TSpace (University of Toronto)
Author: Shantel E. Walcott
Language: English
Subfield: Economics and Econometrics
Domain: Social Sciences
Open Access status: green
OpenAlex ID: W3041654953