Work

The role of APOBEC 3G/3F in shaping early HIV-1 reservoir landscapes

Year: 2017

Type: article

Abstract: of within-host evolution and/or vaccine-induced selection of certain HIV lineages.Conclusions: Results suggest that HIV vaccines may have perturbed the reservoir in a subset of participants.The higher burden of Pol escape in perinatal infection suggests that reservoir escape burden in conserved, rather than in the variable, HIV regions may correlate with untreated infection time as the former regions escape more slowly.Targeting reactivated latent reservoir cells with HIV vaccines will require consideration for the complexity of within-and between-host reservoir diversity and escape burden.PP 4.13

Source: Journal of Virus Eradication

DOI: 10.1016/s2055-6640(20)30610-5

Authors: K. Reddy, G.Q. Lee, B.D. Walker, M.D. Lichterfeld, T. Ndung'u

Institutions: Africa Health Research Institute, Harvard University, Ragon Institute of MGH, MIT and Harvard, Massachusetts Institute of Technology

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950