Differences in the proviral HIV DNA between HIV monoinfected and HIV/HCV coinfected individuals
Year: 2017
Type: article
Abstract: integrated in MLLT3.The MLLT3 protein is responsible for transcriptional elongation in the absence of HIV Tat.HIV integration and dysregulation of MLLT3 may enable low-level production of residual viremia during ART.Conclusions: Although from a single case, we found peripheral Tem may contribute to persistent monotypic plasma virus during ART.Ongoing studies will examine the genome integrity of this provirus.These findings reveal the potential contribution of peripheral Tem in contributing to HIV persistence during successful ART.Further analysis of integration sites in immune cells may elucidate the potential biological pathways manipulated by HIV to allow persistence during ART.
Source: Journal of Virus Eradication
Authors: M.S. Carrillo, B.E. Cartelle, M.G. Arquero, L.M. Carbonero, L. Domínguez-Domínguez, P. Ryan, I. Santos, S. Fuente, O. Bisbal, M. Matarranz, M. Lagarde, A. Moreno, J.M. Castro, E. Mateos, J. Alcamí, S. Resino, A.F. Rodríguez, M. Coiras, V. Briz
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W3042041295