Work

Associations between Aminoquinoline Resistance Genotypes and Clinical Presentations of Plasmodium falciparum Infection in Uganda

Year: 2020

Type: article

Study design: Observational Study

Abstract: = 0.009) malaria. Overall, the PfCRT 76T and PfMDR1 86Y mutations were associated with decreased risk of symptomatic malaria, PfMDR1 1246Y was associated with increased risk of symptomatic malaria, and PfMDR1 184F was associated with decreased risk of severe malaria. These results offer insights into parasite genotypes in children with different presentations, although the basis for the identified associations is likely complex.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00721-20

Authors: Gloria Cuu, Victor Asua, Stephen Tukwasibwe, Sam L. Nsobya, Ann Nanteza, Magambo Phillip Kimuda, Arthur Mpimbaza, Philip J. Rosenthal

Institutions: Infectious Diseases Research Collaboration, Makerere University, University of California, San Francisco

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Fogarty International Center

Awards: University of California Global Health Institute Program for Fellows and Scholars, Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies, Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies in Uganda, Training In Malaria Research in Uganda, G9000203446, G9000261046, G9000324778, University of California Launching Future Leaders in Global Health Research Training Program, Program for Resistance, Immunology, Surveillance & Modeling of Malaria in Uganda (PRISM) Renewal

OpenAlex ID: W3042073881

FWCI: 0.936

Cites: 40

Cited by: 7

Related to: 10