Work

Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study

Year: 2020

Type: article

Study design: Observational Study

Abstract: We read with great interest the study by Coker et al 1 that provided supportive evidence for the role of oral microbiota in gastric cancer. A few studies also highlighted the possible link with oesophageal cancer.2–4 However, there is a lack of robust epidemiologic data on whether periodontal disease and tooth loss, indicators of oral microbial dysbiosis, are associated with these two cancers. Here, we prospectively examined the association of history of periodontal disease and tooth loss with the risk of oesophageal and gastric adenocarcinoma in 98 459 women from the Nurses’ Health Study (1992–2014) and 49 685 men from the Health Professionals Follow-up Study (1988–2016). Dental measures, demographics, lifestyle, and diet were assessed using validated follow-up questionnaires. Self-reported cancer diagnosis was confirmed by review of medical records. We used Cox proportional hazards models to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs). We also examined the independent association of history of periodontal disease and tooth loss in a joint analysis. Over 22–28 years of follow-up, we documented 199 cases of oesophageal adenocarcinoma and 238 cases of gastric adenocarcinoma. History of periodontal disease was associated with a 43% and 52% increased risk of oesophageal adenocarcinoma (multivariable-adjusted HR (aHR) 1.43, 95% CI 1.05 to 1.96) and gastric adenocarcinoma (aHR 1.52, 95% CI 1.13 to 2.04) (table …

Source: Gut

DOI: 10.1136/gutjnl-2020-321949

Authors: Chun-Han Lo, Sohee Kwon, Liang Wang, Georgios Polychronidis, Markus D Knudsen, Rong Zhong, Yin Cao, Kana Wu, Shuji Ogino, Edward L Giovannucci, Andrew T Chan, Mingyang Song

Institutions: Harvard University, Massachusetts General Hospital, Sun Yat-sen University, The First Affiliated Hospital, Sun Yat-sen University, Heidelberg University, Oslo University Hospital, Cancer Registry of Norway, Brigham and Women's Hospital, Huazhong University of Science and Technology, Washington University in St. Louis, Broad Institute

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Foundation for the National Institutes of Health, American Cancer Society, American Institute for Cancer Research, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1051322630, G1288203986, G1327305488, G1410854357, G1787321755, G1849350755, Epigenetic Events and Colorectal Cancer Epidemiology, G2078946450, G2214254730, Marine Omega-3 Fatty Acid, Tumor Immunity and Colorectal Cancer, G2293676233, Inflammation and Colorectal Neoplasia, G2866528883, Alcohol, Gut Dysbiosis, Endotoxemia, and Colorectal Cancer, Accelerating Transdisciplinary Epidemiology of Colorectal Cancer, G3196836363, Early life risk factors and risk of colorectal neoplasia, G369611175, Dietary and Hormonal Determinants of Cancer in Women, G46527388, Marine Omega-3 Polyunsaturated Fatty Acid, Gut Microbiome, and Colorectal Cancer Prevention, G6016387776, G6232781515, Mentored Patient-Oriented Research in Digestive Diseases, G6803175069, Prospective Studies of Diet and Cancer in Men and Women, Integrating diet, lifestyle and tumor tissue molecular subtyping to study the role of adolescent calcium intake on the risk of early onset colorectal neoplasia, G7989194363, G8030658602, G8186992264, G8302776013, G8972268232, Precision Prevention Research Program, Cancer Epidemiology Cohort in Male Health Professionals, G914912716, G959713956

OpenAlex ID: W3042466902

FWCI: 7.118

Cites: 10

Cited by: 63

Related to: 10