Work

The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier

Year: 2020

Type: review

Abstract: Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation. Its sole entry point into mitochondria is through the recently identified mitochondrial pyruvate carrier (MPC). In this review, we report the latest findings on the physiology of the MPC and we discuss how a dysfunctional MPC can lead to diverse pathologies, including neurodegenerative diseases, metabolic disorders, and cancer.

Source: Biomolecules

DOI: 10.3390/biom10071068

Authors: Joséphine Zangari, Francesco Petrelli, Benoît Maillot, Jean-Claude Martinou

Institution: University of Geneva

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,464