Work

Accessible cholesterol is localized in bacterial plasma membrane protrusions

Year: 2020

Type: article

Abstract: Listeria monocytogenes causes listeriosis, a foodborne disease with high mortality rates in vulnerable populations. This Gram-positive intracellular pathogen disseminates through mammalian tissues via actin-based motility and subsequent formation of host plasma membrane (PM) protrusions to cross cellular junctions. Recently, we found that 25-hydroxycholesterol (25HC) potently suppressed L. monocytogenes infection by internalizing a specific pool of cholesterol, termed “accessible cholesterol,” from the PM, preventing induction of membrane protrusions and cell-to-cell spread (1).

Source: Journal of Lipid Research

DOI: 10.1194/jlr.ilr120000891

Authors: Michael E. Abrams, Kristen A. Johnson, Arun Radhakrishnan, Neal M. Alto

Institution: The University of Texas Southwestern Medical Center

Language: English

Topic: Lipid Membrane Structure and Behavior

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430