MicroRNA-101a protects against the H2O2-induced injury on cardiomyocytes via targeting BCL2L11.
Year: 2020
Type: article
Abstract: OBJECTIVE: MicroRNAs (miRs) have been confirmed to be involved in the development of cardiovascular diseases, in spite of numerous studies elucidating the effect and mechanism of miRs in the progression of cardiac ischemia reperfusion injury (I/R), the understanding of their roles is still limited. METHODS: All rats underwent the same I/R procedure, while sham group experienced the surgical procedure but without the ligation of left anterior descending coronary artery (LAD). RESULTS: treatment. Mechanically, BCL2L11 was predicted and then verified to be targeted by miR-101a. Moreover, rescue experiment and RNA pull down further verified the interaction between miR-101a and BCL2L11. CONCLUSIONS: Our findings revealed miR-101a may be a therapeutic target for the therapeutic target for ischemic heart diseases and expanded our understanding of the molecular mechanism underling the progression of I/R injury.
Source: PubMed
Authors: Changlin Zhai, Huilin Hu, Guanmin Tang, Haihua Pan, Yi Zhang, Gang Qian
Institutions: Jiaxing University, Shanghai Jiao Tong University, XinHua Hospital
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3042688726