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Pulmonary Edema in Hb S/β+ thalassemia Patient Leading to Acute Chest Syndrome. A Case Report and Review of Literature

Year: 2020

Type: article

Abstract: Acute chest syndrome (ACS) is associated with prolonged hospitalization and high mortality in sickle cell population. The etiology of ACS is often multifactorial. It is well known that any chest pain that limits ventilation, blood flow or oxygenation establishes the risk of ACS. The independent contributory mechanism is fluid overload, resulting in pulmonary edema. In this report, we present a case of compound heterozygous Hb S/β+ thalassemia in a 32-year-old woman who presented with chest pain complicated by the development of pulmonary edema advancing to acute chest syndrome. We discuss the putative mechanisms might have led to pulmonary edema in this patient including hydration with underlying renal defect, along with a vicious cycle of vascular changes that resulted into pulmonary edema and consequently ACS.

Source: American Journal of Medical Case Reports

DOI: 10.12691/ajmcr-8-10-3

Authors: Hira Chaudhary, Peter Gillette, Michael Ashamalla, Angeleque Hartt, Moro Salifu, Samy I. McFarlane

Institutions: SUNY Downstate Health Sciences University, Hofstra University, Donald & Barbara Zucker School of Medicine at Hofstra/Northwell

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics (clinical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W3042850301

FWCI:

Cites: 7

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Related to: 10