First-in-human demonstration of splenic ultrasound stimulation for non-invasively controlling inflammation
Year: 2020
Type: preprint
Abstract: Hyperinflammation and uncontrolled cytokine release in infections and autoimmune diseases require therapy to reduce the innate immune response. Here, we present first in-human data showing reduction in pro-inflammatory cytokine release with ultrasound stimulation of the spleen in healthy subjects and in rheumatoid arthritis patients. Single cell RNA sequencing reveals a decrease in IL-1β and IL-8 transcript levels in circulating monocytes. There is also a down regulation of pathways involved in TNF and IL-6 production, and IFNγ- and NFκB-regulated genes. Additional pre-clinical studies reveal that ultrasound can boost B cell activation and antibody production. Splenic ultrasound offers a new non-invasive therapy for treating hyperinflammation without compromising the adaptive immune response.
Source: medRxiv
Authors: Rachel S. Graham, Daniel P. Zachs, Victoria Cotero, Catherine D’Agostino, Despoina Ntiloudi, Claire R.W. Kaiser, John Graf, Kirk Wallace, Richard Ramdeo, Thomas R. Coleman, Jeffrey Ashe, John Pellerito, Kevin J. Tracey, Bryce A. Binstadt, Sangeeta S. Chavan, Stavros Zanos, Christopher Puleo, Erik Peterson, Hubert H. Lim
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W3043097823