Adoptive transfer of polarized M2c macrophages ameliorates acute rejection in rat liver transplantation.
Year: 2020
Type: article
Abstract: T-cell infiltration was reduced, whereas the numbers of apoptotic cells increased, in rats treated with M2c. To explore the mechanisms of the protective role of M2c, the numbers of major histocompatibility complex (MHC) class II positive cells were found to be decreased and the expression of N-acetylglucosaminyltransferase V (MGAT5) was up-regulated in M2c infusion groups. Together, these findings demonstrate that polarization of macrophages towards the M2c phenotype ameliorated acute rejection in a rat LT model and may provide a novel and effective therapeutic approach for AR after transplantation.
Source: PubMed
Authors: Peijun Yang, Xuan Zhang, Zhibin Lin, Quancheng Wang, Dongnan Guo, Pengcheng Zhang, Long Yang, Hong Zhang, Rui Ding, Kaishan Tao, Xiao Li, Kefeng Dou
Institutions: Xijing Hospital, Air Force Medical University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3043225966