Work

Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter

Year: 2020

Type: preprint

Abstract: Kynurenic acid (KynA) levels link peripheral metabolic status to neural functions including learning and memory. Since neural KynA levels dampen learning capacity, KynA reduction has been proposed as a therapeutic strategy for conditions of cognitive deficit such as neurodegeneration. While KynA is generated locally within the nervous system, its precursor, kynurenine (Kyn), is largely derived from peripheral resources. The mechanisms that import Kyn into the nervous system are poorly understood. Here, we provide genetic, anatomical, biochemical, and behavioral evidence showing that in C. elegans an ortholog of the human LAT1 transporter, AAT-1, imports Kyn into sites of KynA production.

Source: Genes & Development

DOI: 10.1101/gad.339119.120

Authors: Lin Lin, George A. Lemieux, Osatohanmwen Jessica Enogieru, Kathleen M. Giacomini, Kaveh Ashrafi

Institution: University of California, San Francisco

Language: English

Topic: Tryptophan and brain disorders

Subfield: Biological Psychiatry

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond