Decreased C'-1q protein concentration and agglutinating activity in agammaglobulinaemia syndromes: an inborn error reflected in the complement system.
Year: 1968
Type: article
Study design: Observational Study
Abstract: In both C'(1q) protein and agglutination assays, markedly reduced mean titres (27 and <10% normal, respectively) were observed in Swiss type lymphopenic agammaglobulinaemia. Mean C'(1q) titres were somewhat decreased in other forms of agammaglobulinaemia, but not to the same degree (78 and 46% normal, respectively). C'(1q) titres were normal or elevated in other diseases associated with repeated infections and malignancy. We conclude that the C'(1q) globulins, like the immunoglobulins, characteristically are deficient in agammaglobulinaemia syndromes. Since the greatest C'(1q) deficiencies were seen in lymphopenic agammaglobulinaemia of the Swiss type, titration of C'(1q) seems to be a convenient aid in diagnosing this disease early in life. Thus, the inborn error of agammaglobulinaemia seems to be reflected in the complement system.
Source: PubMed Central
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W304359854