Year: 2019
Type: article
Abstract: Journal of Virus Eradication 2019; 5 (supplement 2): 4-25 19 tissue.Low-level gene transfer from aaV6 was seen in spleen, lymph nodes, and liver.some liver damage, and immune cell infiltration was detected at day 28.efficient gene transfer was seen in the trapezius muscle of animals receiving aaV6 subcutaneously.Conclusions: although well tolerated, aaV6 andretargeted aaV6 vectors transduce rhesus macaque cD4+ t cells inefficiently in vivo.Interestingly, rapamycin treatment allows efficient aaV6 transduction of trapezius muscle following local subcutaneous delivery, offering a possible strategy to deliver HIV neutralizing antibodies.our study provides important safety and efficacy data that will aid study design for future anti-HIV gene therapies.
Source: Journal of Virus Eradication
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W3043881885