Protein Signatures of Centenarians and Their Offspring Suggest Centenarians Age Slower than Other Humans
Year: 2019
Type: article
Study design: Observational Study
Abstract: Using samples from the New England Centenarian Study (NECS), we sought to characterize the serum proteome of 77 centenarians, 82 centenarians' offspring, and 65 age‐matched controls of the offspring (mean ages: 105, 80, and 79 years). We identified 1312 proteins that significantly differ between centenarians and their offspring and controls (FDR < 1%), and two different protein signatures that predict longer survival in centenarians and in younger people. By comparing the centenarian signature with 2 independent proteomic studies of aging, we replicated the association of 484 proteins of aging and we identified two serum protein signatures that are specific of extreme old age. The data suggest that centenarians acquire similar aging signatures as seen in younger cohorts that have short survival periods, suggesting that they do not escape normal aging markers, but rather acquire them much later than usual. For example, centenarian signatures are significantly enriched for senescence‐associated secretory phenotypes, consistent with those seen with younger aged individuals, and from this finding, we provide a new list of serum proteins that can be used to measure cellular senescence. Protein co‐expression network analysis suggests that a small number of biological drivers may regulate aging and extreme longevity, and that changes in gene regulation may be important to reach extreme old age. This centenarian study thus provides additional signatures that can be used to measure aging and provides specific circulating biomarkers of healthy aging and longevity, suggesting potential mechanisms that could help prolong health and support longevity.
Source: Aging Cell
DOI: 10.1111/acel.13290
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,900
Awards: G1233934336, G1242468839, G1248102086, G1789381357, G2495888254, G2857511458, G3362311673, Integrative Omics to enhance therapeutics development for healthy aging, G374919288, G4507648799, G4652745033, Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine, G7333524540, Protein Signatures of APOE2 and Cognitive Aging, A Thermo-Fisher Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer System, G8137636725, Identifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategies, Intercepting head and neck cancer using functional genomics approaches, G9000018859, Identifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategies, Longevity Consortium
OpenAlex ID: W3126029420