Work

The impact of vorinostat and AGS-004, a dendritic cell-based immunotherapy, on persistent HIV-1 Infection

Year: 2019

Type: article

Abstract: supplement 2): 4-25 23 in plasma NFL between study arms at each timepoint, changes in plasma NFL over time and associations with baseline clinical parameters using t-test, linear regression and mixed models.t-cell responses and their correlation with plasma NFL were analysed using rank statistics.Results: all 58 participants included were male, median age 32 years (IQr 28-40) and 40 (69%) white.at baseline, median art duration was 26 weeks (IQr 24-35), median cD4+count was 696 cells/μL (IQr 566-785), and 57(98%) had HIV-1 rNa < 50 copies/mL.No significant differences in plasma NFL were observed between the timepoints (p=0.154), and by study arm for each timepoint (table 44.1).While there was a significantly higher proportion of HIVconsv-specific t-cell responses at week 12 in art+V+V (cD154 + IFN-g + cD4+cells,p< 0.001 and cD107a + IFN-g + cD8+cells, p< 0.001), there was no correlation with plasma NFL concentration.In multivariable analysis, higher plasma NFL at baseline was associated only with older age (p=0.004).Conclusions: reassuringly, we observed no significant change in plasma NFL in rIVer, despite significantly enhanced vaccine-induced HIV-specific t-cell responses in the art+V+V arm.

Source: Journal of Virus Eradication

DOI: 10.1016/s2055-6640(20)31067-0