Work

Deubiquitinase USP7-mediated MCL-1 up-regulation enhances Arsenic and Benzo(a)pyrene co-exposure-induced Cancer Stem Cell-like property and Tumorigenesis

Year: 2020

Type: article

Abstract: The deubiquitinase USP7-mediated MCL-1 up-regulation enhances arsenic and BaP co-exposure-induced CSC-like property and tumorigenesis, providing the first evidence demonstrating that USP7 stabilizes MCL-1 protein during the tumorigenic process.

Source: Theranostics

DOI: 10.7150/thno.47897

Authors: Ping Yang, Jie Xie, Yunfei Li, Hsuan-Pei Lin, William Fenske, Marco Clementino, Yiguo Jiang, Chengfeng Yang, Zhishan Wang

Institutions: University of Kentucky, Guangzhou Medical University, Wuhan University

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

Funders: National Cancer Institute, National Institute of Environmental Health Sciences

Awards: G1497043833, G2526390019, EPIGENETIC MECHANISM OF THE SYNERGISTIC TUMORIGENIC EFFECT OF ARSENICAND BENZO[A]PYRENE CO-EXPOSURE

OpenAlex ID: W3044577069

FWCI: 0.974

Cites: 45

Cited by: 20

Related to: 10