Year: 2015
Type: article
Study design: Observational Study
Abstract: out with non-parametric methods and Spearman's correlation coefficient.Results: Total HIV DNA was detected in 96.2% of the samples, with a median proviral DNA of 136 copies/10 6 cells (IQR: 63-301).Patients were stratified in two groups: above and below this median.We observed lower HIV-1 DNA in younger patients with shorter time from diagnosis and lower levels of zenith plasma viremia.Additionally, low reservoir was associated with higher nadir CD4 T cells and higher CD4/CD8 ratio.We also found that patients who initiated therapy with raltegravir harbored a significantly lower reservoir.LoViReT patients represented 20 subjects (6.3%) with HIV-1 DNA<10 copies/10 6 cells, including 12 undetectable patients.These subjects were younger, had been diagnosed more recently, and had higher nadir CD4 T cells when compared with the rest of patients.We also observed that LoViReT patients had smaller envelope trimer-specific antibody titers than patients with high latent reservoir.Conclusion: LoViReT patients harbor an extremely low HIV-1 proviral reservoir during suppressive cART despite not being involved in any HIV eradication-based strategy.A more conserved immune system seems to characterize this infrequent cohort.PP 3.11
Source: Journal of Virus Eradication
Authors: J. Hattori, V. Boltz, W. Shao, M. Kearney, F. Maldarelli
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W3044832124