Work

14 Effect of substances of abuse on HIV DNA decay during antiretroviral therapy started during early HIV infection

Year: 2016

Type: article

Abstract: month 12. Difference in measurable HIV DNA was statistically significant only when comparing seminal plasma to sperm fractions at week 0 (p=0.02).HIV RNA was detected in only 1/5 seminal plasma specimens with measurable HIV DNA at month 6 and in 0/3 seminal plasma specimens with measurable HIV DNA at month 12.Conclusions: HIV DNA was measurable in seminal plasma fractions at least to month 12 after ART initiation while HIV RNA became undetectable in the same specimens.Further study is necessary to characterize semen as a HIV reservoir and determine reactivation potential and transmissibility.

Source: Journal of Virus Eradication

DOI: 10.1016/s2055-6640(20)30959-6