Year: 2015
Type: article
Abstract: Results: The R263K substitution was associated with a progressive decline in the levels of integrated HIV DNA.Conclusions: The R263K resistance substitution impairs the long-term ability of HIV to integrate, possibly decreasing the size of the viral reservoir in individuals who develop resistance against dolutegravir.Therapeutic strategies using dolutegravir to decrease the HIV reservoir should be explored.
Source: Journal of Virus Eradication
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W3044897594