Year: 2020
Type: review
Abstract: Hematopoietic stem cells (HSC) reside in the bone marrow (BM) within a specialized micro-environment, the HSC niche, which comprises several cellular constituents. These include cells of mesenchymal origin, endothelial cells and HSC progeny, such as megakaryocytes and macrophages. The BM niche and its cell populations ensure the functional preservation of HSCs. During infection or systemic inflammation, HSCs adapt to and respond directly to inflammatory stimuli, such as pathogen-derived signals and elicited cytokines, in a process termed emergency myelopoiesis, which includes HSC activation, expansion, and enhanced myeloid differentiation. The cell populations of the niche participate in the regulation of emergency myelopoiesis, in part through secretion of paracrine factors in response to pro-inflammatory stimuli, thereby indirectly affecting HSC function. Here, we review the crosstalk between HSCs and cell populations in the BM niche, specifically focusing on the adaptation of the HSC niche to inflammation and how this inflammatory adaptation may, in turn, regulate emergency myelopoiesis.
Source: Frontiers in Immunology
Institutions: Democritus University of Thrace, German Cancer Research Center, National Center for Tumor Diseases, Nationales Centrum für Tumorerkrankungen Dresden, German Cancer Research Center (DKFZ) Dresden, University Hospital Carl Gustav Carus, Technische Universität Dresden, University of Pennsylvania
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Awards: Del-1: Molecular and Cellular Targets in Periodontitis, G3319228230, Aging and dysfunction of progenitor niches: Role of Del-1, Ανοσομεταβολική ρύθμιση της κόγχης των αιμοποιητικών στελεχιαίων κυττάρων στη μυελοδυσπλασία και τη γήρανση, Local endogenous regulators of functional immune plasticity in the periodontium
OpenAlex ID: W3044908331