Secondary hyperparathyroidism and hypovitaminosis D one year after bypass surgery : a retrospective cohort study
Year: 2019
Type: conference-abstract
Abstract: Background: Patients with obesity submitted to bariatric procedures have a high risk of secondary hyperparathyroidism (SHPT; up to 53%) and hypovitaminosis D (33 to 96.7%).These comorbidities could imply in future adverse bone conditions.The aim of this study was to evaluate vitamin D deficiency and SHPT in South Brazilian patients after one year of Roux-en-Y gastric bypass (RYGB).Methods: In this retrospective cohort study vitamin D deficiency was defined as serum 25(OH) vitamin D lower than 20 ng/ml and SHPT as PTH higher than 68 pg/ml postoperative, in patients with normal serum creatinine and calcium.Bone mineral density (BMD) was estimated by DXA -Lunar (g/cm²).Results: From a total of 205 patients who underwent bypass surgery between March 2016 and November 2018 100 patients were included (50.6 ± 10.1 years, 12% non-white ethnicity, 91% female, 54.2 ± 19.2 months of follow-up).Preoperative and current BMI were 48.9 ± 7,8 and 33.4 ± 4.8 kg/m², respectively, with 65.5 ± 15.8% excess body weight loss.Multivitamin supplements were used by 85% and calcium tablets by 51%; 90% consumed dairy products on daily basis.In the last medical visit, 69% of patients were taking vitamin D [23,070 IU weekly (P25-75 14,000 -29,750)] and the mean 25(OH)D was 20.3 ± 8.1 ng/ml at first and 24.1 ± 8.1 ng/ml in the last evaluation (p<0.01),resulting in a 49% prevalence of hypovitaminosis D firstend 25% with n=98 .SHPT was identified in 56% [PTH 78.0 pg/dl (P25-75 55.1 -93.6)].An inverse correlation was observed between PTH and BMD in total hip (r = -0.221;p<0.05 ) and with vitamin D (r = -0.260;p<0.01).No correlation between PTH and total BMD and proximal femur was observed.Conclusions: Vitamin D deficiency and SHPT were frequent after bypass surgery, and BMD was inversely correlated to PTH in these patients.
Institution: Universidade Federal do Rio Grande do Sul
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3044985313