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Modified mRNA-LNP Vaccines Confer Protection against Experimental DENV-2 Infection in Mice

Year: 2020

Type: article

Abstract: Dengue virus (DENV) infection is a major global public health concern, and there is no effective vaccine for it. In this study, we describe the design and characterization of three nucleotide-modified mRNA vaccines (prME-mRNA, E80-mRNA, and NS1-mRNA) for DENV-2. Our results showed that vaccination with E80-mRNA alone or a combination of E80-mRNA and NS1-mRNA can induce high levels of neutralizing antibodies and antigen-specific T cell responses; furthermore, these vaccines confer complete protection against DENV-2 challenge in immunocompetent mice. These data provide foundations for further development of a tetravalent DENV vaccine based on nucleotide-modified mRNA.

Source: Molecular Therapy — Methods & Clinical Development

DOI: 10.1016/j.omtm.2020.07.013

Authors: Mengling Zhang, Jin Sun, Min Li, Xia Jin

Institutions: Chinese Academy of Sciences, Fudan University, Institut Pasteur of Shanghai, Shanghai Public Health Clinical Center, University of Chinese Academy of Sciences

Language: English

Topic: Mosquito-borne diseases and control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,500