The SMAC mimetic AZD5582 reverses HIV latency as a single agent in resting primary CD4+ T cells
Year: 2019
Type: article
Abstract: 4-25 14 analyzed.Datasets were publicly available through the sequence read archive.Results: We found that HerV loci were differentially expressed in activated vs. resting cells.a total of 641 HerV loci were upregulated in activated cells and 550 loci were downregulated in activated cells.We also found that HerV-K11_8p23.1b was statistically differentially expressed (p=0.015) in Infected and activated vs. Uninfected and activated cells.Most important, when comparing Latently Infected vs. Uninfected Latent we found 7 statistically differentially expressed HerV loci.Furthermore, we also identified 3 HerV loci differentially expressed between Infected and Uninfected regardless of their activation status.Conclusions: our results reveal an important and unreported finding that suggests a role for HerVs during HIV-1 latency.the differential expression of HerV derived transcripts in HIV-1 latent infected cells may shed light into new strategies for the efficient eradication of latently infected cells.these novel insights could be explored to develop clinical therapeutic approaches to effectively eradicate HIV-1.
Source: Journal of Virus Eradication
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W3045204414