Work

Knockout of sulfatase 2 is associated with decreased steatohepatitis and fibrosis in a mouse model of nonalcoholic fatty liver disease

Year: 2020

Type: article

Abstract: We report for the first time that in wild-type (WT) mice, fast-food diet (FFD) induced a threefold increase in hepatic Sulf2 mRNA and a 2.2-fold increase in sulfatase 2 (SULF2) protein expression compared with WT mice on standard chow diet (SC). We showed that knockout of SULF2 ameliorates FFD-induced obesity, hyperlipidemia, steatohepatitis, and fibrosis. These data, along with work from other laboratories, suggest that SULF2 may be critical to the ability of the liver to progress to nonalcoholic steatohepatitis and fibrosis in conditions of overnutrition.

Source: American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI: 10.1152/ajpgi.00150.2019

Authors: Tae Hyo Kim, Bubu A. Banini, Faizal Z. Asumda, Nellie A. Campbell, Chunling Hu, Catherine D. Moser, Abdirashid M. Shire, Shaoshan Han, Chenchao Ma, Anuradha Krishnan, Taofic Mounajjed, Thomas A. White, Gregory J. Gores, Nathan K. LeBrasseur, Michael R. Charlton, Lewis Rowland Roberts

Institutions: Mayo Clinic, Gyeongsang National University, Gyeongsang National University Hospital, Mayo Clinic Comprehensive Cancer Center (Minnesota)

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Mayo Foundation for Medical Education and Research, National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences

Awards: G1044130170, G1828094709, G311967391, G3564887138, G601308626, G732393567, G8361455225, Molecular Pathogenesis of Hepatocellular Carcinoma, G9000061277, G9000066704, G9000226708, G9000257663, Mayo Clinic Comprehensive Cancer Center Support Grant, Mayo Center for Cell Signaling in Gastroenterology, Yale Clinical and Translational Science Award

OpenAlex ID: W3045384480

FWCI: 0.614

Cites: 33

Cited by: 13

Related to: 10