Work

cDC1 dysregulation in cancer: An opportunity for intervention

Year: 2020

Type: article

Abstract: Conventional dendritic cells driven by the transcription factor Batf3 (cDC1 cells) are critical for the activation and maintenance of tumor-specific CD8+ T cells. In this issue of JEM, Lin et al. (https://doi.org/10.1084/jem.20190673) demonstrate systemic dysfunction of cDC1 cells in pancreatic cancer, which offers potential treatment strategies to expand the benefit of checkpoint blockade immunotherapy.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20200816

Authors: Thomas F. Gajewski, Kyle R. Cron

Institution: University of Chicago

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Cancer Institute