Work

Microglia and astrocyte dysfunction in parkinson's disease

Year: 2020

Type: review

Abstract: While glia are essential for regulating the homeostasis in the normal brain, their dysfunction contributes to neurodegeneration in many brain diseases, including Parkinson's disease (PD). Recent studies have identified that PD-associated genes are expressed in glial cells as well as neurons and have crucial roles in microglia and astrocytes. Here, we discuss the role of microglia and astrocytes dysfunction in relation to PD-linked mutations and their implications in PD pathogenesis. A better understanding of microglia and astrocyte functions in PD may provide insights into neurodegeneration and novel therapeutic approaches for PD.

Source: Neurobiology of Disease

DOI: 10.1016/j.nbd.2020.105028

Authors: Tae-In Kam, Jared T. Hinkle, Ted M. Dawson, Valina L. Dawson

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500