HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis
Year: 2020
Type: article
Study design: Observational Study
Abstract: We analysed 312 drug-resistant genomes of Mycobacterium tuberculosis (Mtb) collected from HIV coinfected and HIV negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant Mtb strains isolated from HIV coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low fitness rpoB variants can thrive in the context of reduced host immunity.
DOI: 10.1128/aac.00782-20
Authors: Chloé Loiseau, Daniela Brites, Miriam Reinhard, Kathrin Zürcher, Sonia Borrell, Marie Ballif, Lukas Fenner, Helen Cox, Liliana K. Rutaihwa, Robert J. Wilkinson, Marcel Yotebieng, E Jane Carter, Alash’le Abimiku, Olivier Marcy, Eduardo Gotuzzo, Anchalee Avihingsanon, Nicola Zetola, Basra Doulla, Erik C. Böttger, Matthias Egger, Sebastien Gagneux
Institutions: Swiss Tropical and Public Health Institute, University of Basel, University of Bern, University of Cape Town, Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, Ifakara Health Institute, The Francis Crick Institute, Imperial College London, Albert Einstein College of Medicine, Moi University, Institute of Human Virology, Université de Bordeaux, Inserm, Bordeaux Population Health, Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt, Chulalongkorn University, HIV Netherlands Australia Thailand Research Collaboration, University of Pennsylvania, University of Zurich
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funders: National Science Foundation, Foundation for the National Institutes of Health, Universität Basel, Wellcome Trust, Francis Crick Institute, Cancer Research UK, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Cancer Institute, National Institute of Allergy and Infectious Diseases, Fogarty International Center, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Child Health and Human Development, U.S. National Library of Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G100239846, G1265315430, G1459148076, G1508009684, Population genomics of drug resistant tuberculosis, G162807682, G1825977350, G1859885209, G1866914209, G2006052962, G2374936369, G240136927, G2466661058, G2517021052, G2539165023, G2542180245, G2602991252, G2606189360, G2915904895, G295270083, G3026053108, G3090742097, G325158278, G3475612999, G3527861497, G3544296662, Host directed therapies against tuberculosis., G3964318989, G4115567365, G4118374008, G4136037232, G4176875957, G4275245238, G4290796093, G4313704104, G4346769292, G4536063133, G4592013985, G5012601499, G5355865466, G5356295135, Centre for Infectious Diseases Research in Africa (CIDRI-Africa), G569290698, A systems approach to evaluating prospects for the control of drug-resistant tuberculosis in Khayelitsha, South Africa., Host directed therapies against tuberculosis., G5785870036, Population genomic and phenotypic determinants of host tropism in the Mycobacterium tuberculosis Complex affecting livestock and humans, G596821015, G5984172584, G617683515, G6199130729, G6246704175, G6256613848, G6354378175, G6607000333, G6761848313, G6796974715, G6965689831, G7065286958, G724356770, G7300457456, G7364435899, G768658969, Forschungspauschale Forschungsratspräsident SNF, Mixed strain infections in human tuberculosis: their role in biology, epdemiology and clinical outcome, G789719663, G790109484, G7927980121, G8006438368, G8690818240, G8717451453, G8800573163, G8889343963, G9000041915, G9000052486, G9000103628, G9000103636, G9000170186, North American AIDS Cohorts on Collaboration and Design (NAACCORD), Central Africa International Epidemiology databases to Evaluate AIDS, Caribbean, Central, and South America network for HIV Epidemiology (CCASAnet), G970508597
OpenAlex ID: W3045873240