Year: 2018
Type: article
Study design: Observational Study
Abstract: Objective: Heparan sulfate proteoglycans (HSPG) are main components of remodeling the extracellular matrix (ECM). Heparanase (HPSE) can cleave the HSPG and alter the structural integrity of the ECM. The present research was to investigate the role of HPSE in recurrent spontaneous abortion (RSA). Study Design: Reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemical methods were used to determine the expression of heparanase (HPSE) in the villus of the human normal pregnancy and RSA. Results: The expressions of HPSE mRNA and protein in the normal group were significantly greater in comparison with those in the spontaneous abortion group (p Conclusion: The HPSE participates in the procedure of normal pregnancy, and the lower expression of HPSE may lead to the spontaneous abortion.
Authors: Yaqin Mu, Jian Wang, Runhua Liu, Caixia Qi, Guoping Xi, Fuxi Zhao, angyan Zhu
Institution: Shanxi Datong University
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Funder: Shanxi Datong University
OpenAlex ID: W3045958382