Regulation of Protein 4.1-Membrane Associations by a Phosphoinositide
Year: 2020
Type: book-chapter
Abstract: The cortical cytoskeleton of the vertebrate erythrocyte is an interconnecting meshwork formed by oligomerization of the major component, spectrin, and by associations between spectrin and actin [ 1 – 3 ]. The rodlike spectrin dimer endto-end associates to form tetramers and by further addition of dimers, higher oligomers [ 4 ]. At the end of spectrin opposite to the oligomerization site, spectrin associates with actin [ 5 – 9 ]. In the erythrocyte, spectrin and actin are tightly bound to the plasma membrane. This association is mediated by proteins that serve to link spectrin to transmembrane protein receptors [ 1 – 3 ]. Spectrin, in the absence of actin, binds with high affinity to the membrane through an interaction with ankyrin, which in turn associates with the anion channel band 3 [ 1 ] •
Source: CRC Press eBooks
Author: Richard A. Anderson
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W3045967845