Year: 2020
Type: review
Abstract: Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to dynamic and functionally active organelles involved in a variety of cellular functions. Studies have now informed significant roles for LDs in cellular signaling, metabolic disease, and inflammation. While lipid droplet biology has been well explored in peripheral organs such as the liver and heart, LDs within the brain are relatively understudied. The presence and function of these dynamic organelles in the central nervous system has recently gained attention, especially in the context of neurodegeneration. In this review, we summarize the current understanding of LDs within the brain, with an emphasis on their relevance in neurodegenerative diseases.
Source: Frontiers in Neuroscience
Institution: University of Kentucky
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,950
Awards: G1546050883, Center of Research on Obesity and Cardiovascular Diseases, Astrocyte Lipid Droplets as a Novel Mechanism for Impaired Glucose Metabolism in the E4 and AD Brain, Changing the energy substrate balance: Does APOE2 promote glucose usage to protect from Alzheimer's Disease?, APOE and the PPP: Glucose Metabolism and Oxidative Stress in Alzheimer's Disease
OpenAlex ID: W3046107762