Work

Radical coupling of β-ketoesters and amides promoted by Brønsted/Lewis acids

Year: 2020

Type: article

Abstract: Recent advances in photocatalysis have enabled radical methods with complementary chemoselectivity to established two electron bond forming approaches. While this radical strategy has previously been limited to substrates with favorable redox potentials, Brønsted/Lewis acid activation has emerged as a means of facilitating otherwise difficult reductions. We report herein our investigations into the Lewis acid-promoted redox activation of β-ketocarbonyls in a model photocatalytic radical alkylation reaction. Rapid evaluation of substrates and reactions conditions was achieved by high throughput experimentation using 96-well plate photoreactors.

Source: Green Synthesis and Catalysis

DOI: 10.1016/j.gresc.2020.06.003

Authors: Joshua L. Zhu, Stephen W. Laws, Michael J. Rourke, Karl A. Scheidt

Institution: Northwestern University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Northwestern University, National Cancer Institute, National Institute of General Medical Sciences

Awards: G270006530, G2794346803, G542451570, G749739012