Work

Total synthesis of biseokeaniamides A–C and late-stage electrochemically-enabled peptide analogue synthesis

Year: 2020

Type: article

Abstract: -acetal intermediates are engaged with electron-rich aromatics and organometallic reagents to forge modified amino acids and peptides. The value of this late-stage modification method is highlighted by the expedient and divergent production of bioactive peptide analogues, including compounds which exhibit enhanced cytotoxicity relative to the biseokeaniamide natural products.

Source: Chemical Science

DOI: 10.1039/d0sc03701j

Authors: Yutong Lin, Lara R. Malins

Institution: Australian National University

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funder: Australian Research Council

Award: A radical approach to unnatural amino acids and peptide-based antibiotics