Work

Long‐term trajectories of medicine use among older adults experiencing polypharmacy in Australia

Year: 2020

Type: article

Abstract: AIMS: To explore longitudinal changes in the number and type of medicines used among older people who experience polypharmacy. METHODS: We used pharmaceutical claims for a 10% sample of Australian Pharmaceutical Benefits Scheme beneficiaries to identify people aged 70 years and older who were exposed to 5 or more medicines on 15 February 2014. Using group-based trajectory modelling, we explored changes in the quarterly number and type of medicines used over a 5-year period (2014-2018). RESULTS: In our cohort of 98 539 people, we identified 2 predominant groups of medicine use: sustained polypharmacy (77% of people, 4 trajectories); and decreasing medicine use (23%, 3 trajectories). Within the sustained polypharmacy group, people in trajectories with a lower mean number of medicines (e.g. 6 unique medicines) had relatively stable trajectories, while those using a higher number of medicines (e.g. 15 unique medicines) experienced greater seasonal variation in the number and type of medicines used. On average, people continued to use 2/3 of their medicines (chemical substance level) across adjacent quarters. Within groups of decreasing medicine use, the most common trajectory was a slight drop in medicines within 3 months. Overall, 79% of people still experienced polypharmacy after 1 year. CONCLUSION: Polypharmacy among older people is a sustained phenomenon, reflecting the chronic nature of multimorbidity within this population. However, there is an underlying volatility in the nature of medicines involved, reflecting both changes in treatment and seasonal fluctuation in dispensing. Ongoing prescribing vigilance is required, particularly for patients using very large amounts of medicines.

Source: British Journal of Clinical Pharmacology

DOI: 10.1111/bcp.14504

Authors: Michael O. Falster, Rayan Charrier, Sallie‐Anne Pearson, Nicholas A. Buckley, Benjamin Daniels

Institutions: UNSW Sydney, Centre for Big Data Research in Health, École Polytechnique, The University of Sydney

Language: English

Topic: Pharmaceutical Practices and Patient Outcomes

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green