Toward a Global and Reproducible Science for Brain Imaging in Neurotrauma: The ENIGMA Adult Moderate/Severe Traumatic Brain Injury Working Group
Year: 2019
Type: preprint
Abstract: The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a major challenge for scientific advances and clinical translation. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Adult moderate/severe TBI (AMS-TBI) working group aims to be a driving force for new discoveries in AMS-TBI by providing researchers world-wide with an effective framework and platform for large-scale cross-border collaboration and data sharing. Based on the principles of transparency, rigor, reproducibility and collaboration, we will facilitate the development and dissemination of multiscale and big data analysis pipelines for harmonized analyses in AMS-TBI using structural and functional neuroimaging in combination with nonimaging biomarkers, genetics, as well as clinical and behavioral measures. Ultimately, we will offer investigators an unprecedented opportunity to test important hypotheses about recovery and morbidity in AMS-TBI by taking advantage of our robust methods for largescale neuroimaging data analysis. In this consensus statement we outline the working group’s short-term, intermediate, and long-term goals.
Authors: Alexander Olsen, Talin Babikian, Erin D. Bigler, Karen Caeyenberghs, Virginia Conde, Kristen Dams-O’Connor, Ekaterina Dobryakova, Helen Genova, Jordan Grafman, Asta Håberg, Ingrid Heggland, Torgeir Hellstrøm, Cooper B Hodges, Andrei Irimia, Ruchira Jha, Paula Johnson, Vassilis Koliatsos, Harvey S Levin, Lucia Li, Hannah Lindsey, Abigail Livny-Ezer, Marianne Løvstad, John Medaglia, David Menon, Stefania Mondello, Martin Monti, Virginia Newcombe, Agustin Petroni, Jennie Ponsford, David Sharp, Gershon Spitz, Lars T. Westlye, Paul Thompson, Emily L. Dennis, David F Tate, Elisabeth A. Wilde, Frank Hillary
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Funders: U.S. Department of Defense, Brigham Young University, Norges Teknisk-Naturvitenskapelige Universitet, National Institute for Health and Care Research, European Commission, Australian Catholic University, Transport Accident Commission, Norges Forskningsråd, St. Olavs Hospital Universitetssykehuset i Trondheim, UK Dementia Research Institute, National Institutes of Health, Medical Research Council, National Health and Medical Research Council, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, Medical Research and Materiel Command
Awards: G1157805208, G2214508145, G2667952146, G3455626259, G3840218660, G4119534169, G4160228958, G434337789, G4345613377, G4421633565, G4700852728, G4846637803, Longitudinal Tracking of Traumatic Brain Injury: Advanced Connectomics, G5458267808, G5850682332, Translational assessment of sulfonylurea receptor-1 as a biomarker and therapeutic target for cerebral edema in traumatic brain injury, G5984184289, ENIGMA Center for Worldwide Medicine, Imaging & Genomics, G6547256859, G675246756, G6758941665, G700495459, G8166743225, G8551711365, G8566760292, G9000014096, G9000035376, G9000044152, G9000047439, G9000060504, G9000116029, G9000159916, G9000210308, G9000250461, G9000259959, G9000307569, TBI-RELATED RISK FACTORS FOR ALZHEIMER'S DISEASE: EARLY DETECTION AND PROGNOSIS VIA MULTIMODAL BRAIN IMAGING AND CONNECTOMICS
OpenAlex ID: W3046478265